Anti-GS Linker Affinity Resin FF

A linker is an amino acid chain that connects two fused proteins, allowing for the appropriate separation of protein functional domains or the maintenance of necessary inter-domain interactions. The most widely known flexible linker is the poly-Glycine-Serine (GS) linker. The GS Linker includes various forms, such as (GS)n, (GGS)n, (GGGS)n, (GGGGS)n, etc. These GS linkers are widely used in connecting bispecific antibodies, antibody fusion proteins, single-chain antibodies, peptides and ADCs, etc.
GenScript’s Anti-GS Linker Affinity Resin FF (Cat. No. L01036) is designed for purification of proteins, antibodies and compounds containing (GnS)m linker (n≥2, m≥2) from commonly used protein expression systems such as bacteria, yeast and mammalian cells. The GS linker fusion protein in cell lysate can specifically bind to the anti-GS linker antibody coupled to the resin. Nonspecific binding reactions are eliminated by stringent washing steps, and the purified target protein is eluted with a high recovery rate. Table 1 lists the main characteristics of Anti-GS Linker Affinity Resin FF.